Exercise May Not Slow Muscle Ageing

Posted by juggernautPT on April 23, 2013

Exercise May Not Slow Muscle Ageing
Exercise May Not Slow Muscle Ageing

Genetic research from the UK suggests that the belief that exercise can slow muscle ageing may be erroneous.

Jamie Timmons, lead study author and professor of Systems Biology in the School of Sport, Exercise and Health Sciences at Loughborough University, said ‘When we look at the changes in human muscle with age, in both people from the UK and the USA, we do not observe physical activity altering the age-related biological changes.’

Although Timmons conceded that exercise does result in ‘good functional effects’ for some older people, in others it has no effect due to their predisposition to be unable to grow muscle. Age, they said, has its own effect on muscle ageing, regardless of exercise.

A 20-week endurance training program resulted in the study subjects who exhibited suppressed mTOR signalling gaining the most lean tissue mass. Study subjects whosegenes didn’t suppress the mTOR signalling did not experience any slowing of muscle ageing (according to biological markers), regardless of how hard they worked out for the entire study.

‘We were able to identify unique gene pathways associated with human muscle growth and age and were able to conclude that human muscle age-related molecular processes appear distinct from the processes directly regulated by those of physical activity’ the study authors wrote.

 

Source: PLOS Genetics

 


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